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      https://www.ias.ac.in/article/fulltext/jgen/099/0022

    • Keywords

       

      polymorphism; genotypes; mycoplasma pneumonia; immune factors; resistance; susceptibility

    • Abstract

       

      Major histocompatibility complex (MHC) polymorphisms are associated with animal and human diseases. However, only a few studies have reported an association between MHC polymorphisms and mycoplasma ovipneumonia (MO). In the present study, three resistance/susceptibility genotypes associated with MO were identified by polymerase chain reaction-restriction fragment length polymorphism genotyping, assessing the clinical and pathological features, and examining the immune factors. The current results showed that MvaI bb and HaeIII ee were dominant genotypes in the susceptible Hu population, while MO-resistant populations, Dorper and D 9 H hybrids, were dominated by the MvaI cc and HaeIII dd genotypes, suggesting that MvaI cc and HaeIII dd genotypes might be associated with the trait of MO resistance. Further, the clinical symptoms and pathological morphology in the susceptibility group infected with MO were more severe than those in the resistant groups infected similarly. The data on the changes in the immune factor responses were utilized to deduce the molecular mechanism underlying the MO resistance/susceptibility. The results showed that the susceptible genotypes promote the inflammatory responses by inducing a high expression of TNFa, IFNc, IL-4, IL-6, and IL-1b, while the resistant genotypes inhibit the inflammatory response by increasing the expression of IL-2 and IL-10 significantly. This finding would provide the theoretical guidance for propagating sheep breeds that are highly resistant to MO.

    • Author Affiliations

       

      KAISHENG WANG1 2 XIANXIA LIU1 QIONGQIONG LI3 KEXING WAN3 RUI GAO3 GUOHUA HAN1 CHAOCHEN LI1 MENGSI XU4 BIN JIA1 XIAOYUN SHEN5 6

      1. College of Animal Science and Technology, Shihezi University, Shihezi 832000, Xinjiang, People’s Republic of China
      2. College of Biology and Pharmacy, Yulin Normal University, Yulin 537000, Guangxi, People’s Republic of China
      3. School of Medicine, Shihezi University, Shihezi 832000, Xinjiang, People’s Republic of China
      4. State Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Sciences, Shihezi 832000, Xinjiang, People’s Republic of China
      5. School of Life Sciences and Engineering, Southwest University of Science and Technology, Mianyang 621000, Sichuan, People’s Republic of China
      6. School of Karst Science, Guizhou Normal University/State Engineering Technology Institute for Karst Desertification Control, Guiyang 550000, Guizhou, People’s Republic of China
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    • Supplementary Material

       
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