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      https://www.ias.ac.in/article/fulltext/jgen/098/0099

    • Keywords

       

      association test; genomic imprinting; X-chromosome inactivation.

    • Abstract

       

      Studies have shown that many complex diseases are sex-determined. When conducting genetic association studies on Xchromosome, there are two important epigenetic factors which should be considered simultaneously: X-chromosome inactivation and genomic imprinting. Currently, there have been several association tests accounting for the information on X-chromosome inactivation. However, these tests do not take the imprinting effects into account. In this paper, we propose a novel association test simultaneously incorporating X-chromosome inactivation and imprinting effects based on case–parent trios and control–parent trios for female offspring and case–control data for male offspring, denoted by MLRXCII. Extensive simulation studies are carried out to investigate the type I error rate and the test power of the proposed MLRXCII . Simulation results demonstrate that the proposed test controls the type I error rate well andis more powerful than the existing method when imprinting effects exist. The proposed MLRXCII test is valid and powerful in genetic association studies on X-chromosome for qualitative traits and thus is recommended in practice.

    • Author Affiliations

       

      WEI LIU1 BEI-QI WANG1 GUOJUN LIU-FU1 WING KAM FUNG2 JI-YUAN ZHOU1

      1. State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, People’s Republic of China
      2. Faculty of Science, Department of Statistics and Actuarial Science, The University of Hong Kong, Pok Fu Lam, Hong Kong, People’s Republic of China
    • Dates

       
  • Journal of Genetics | News

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