• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jgen/098/0035

    • Keywords

       

      acute myeloid leukaemia; noncoding somatic mutation; HOXA cluster.

    • Abstract

       

      Noncoding somatic mutations have been demonstrated to play important role in tumourigenesis. Here we show that there exists an acute myeloid leukaemia associated noncoding somatic mutation at 3′ terminal of conserved HOXA cluster. The mutation was identified in the bone marrow blasts but not peripheral blood mononuclear cells or buccal cells of two M3 (acute promyelocytic leukaemia, APL) type patients from 45 acute myeloid leukaemia patients. The mutation also existed in a pair of twins one of them developed acute myeloid leukaemia M4 (acute myelomonocytic leukaemia) type. The mutation resides in about 2-kb downstream of HOXA1 gene where a functional retinoic acid response element is located and also bound by histone demethylase KDM3B. Reporter assay showed that the mutation results in the upregulation of transcriptional activity and unresponsiveness to retinoic acid receptor. To sum up, we identified a new acute myeloid leukaemia associated noncoding somatic mutation.

    • Author Affiliations

       

      XIN XU1 2 LEI SONG1 YAO ZHAO1 LIN WANG3 XINJING ZHANG1 ZHENMING SHEN1 CHUNLING ZHAO2 ZHENBO HU1

      1. Laboratory for Stem Cell and Regenerative Medicine, The Affiliated Hospital of Weifang Medical University, Weifang 261053, Shandong, People’s Republic of China
      2. College of Bioscience and Technology, Weifang Medical University, Weifang 261053, Shandong, People’s Republic of China
      3. The School of Physics and Optoelectronic Engineering, Weifang University, Weifang 261061, Shandong, People’s Republic of China
    • Dates

       
  • Journal of Genetics | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.