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      https://www.ias.ac.in/article/fulltext/jgen/098/0020

    • Keywords

       

      C-reactive protein; genomewide association study; Indians; metabolic diseases.

    • Abstract

       

      Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammation, and is also associated with metabolic diseases. Genomewide loci regulating CRP level in Indian population, a high-risk group for metabolic illness, is unexplored. Therefore, we aimed to discover common polymorphisms associated with plasma CRP level in 4493 Indians of Indo-European origin using genomewide association study. Genomewide strong associations of two known intronic variants in hepatocyte nuclear factor-1 α gene (HNF1A)were identified among Indian subjects. We also detected prior associations of several variants in/near metabolic and inflammatory process genes: APOC1, LEPR, CRP, HNF4A, IL6R and APOE with modest associations. This study confirms that Indians from Indo-European origin display similar core universal genetic factors for CRP levels.

    • Author Affiliations

       

      GAURI PRASAD1 2 ANIL K. GIRI1 2 INDICO CONSORTIUM ANALABHA BASU3 NIKHIL TANDON4 DWAIPAYAN BHARADWAJ2 5

      1. Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110 020, India
      2. Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi 110 020, India
      3. National Institute of Biomedical Genomics, Netaji Subhas Sanatorium (Tuberculosis Hospital), Kalyani, West Bengal 741 251, India
      4. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110 029, India
      5. Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi 110 067, India
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    • Supplementary Material

       
  • Journal of Genetics | News

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