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      https://www.ias.ac.in/article/fulltext/jgen/097/03/0715-0727

    • Keywords

       

      soluble NSF-attachment protein receptor; phosphoinositide; autophagy; retromer; Rab GTPase; endocytosis; synaptic vesicle

    • Abstract

       

      Parkinson’s disease (PD), the second most common neurodegenerative disease after Alzheimer’s disease, develops sporadically, and its cause is unknown. However, 5–10% of PD cases are inherited as monogenic diseases, which provides a chance to understand the molecular mechanisms underlying neurodegeneration. Over 20 causative genes have already been identified and arebeing characterized. These PD-associated genes are broadly classified into two groups: genes involved in mitochondrial functions and genes related to membrane dynamics such as intracellular vesicle transport and the lysosomal pathway. In this review, we summarize the latest findings on the mechanism by which members of the latter group of PD-associated genes regulate membrane dynamics, and we discuss how mutations of these genes lead to dopaminergic neurodegeneration.

    • Author Affiliations

       

      TSUYOSHI INOSHITA1 CHANGXU CUI1 NOBUTAKA HATTORI1 2 YUZURU IMAI1 2

      1. Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
      2. Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
    • Dates

       
  • Journal of Genetics | News

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