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      https://www.ias.ac.in/article/fulltext/jgen/097/01/0235-0251

    • Keywords

       

      human immunodeficiency virus; susceptibility; interleukin; gene polymorphism; single-nucleotide polymorphisms; meta-analysis.

    • Abstract

       

      Some subjects are repeatedly exposed to human immunodeficiency virus (HIV), yet they remain uninfected. This suggests the existence of host-resistance mechanisms. The current study synthesizes the evidence regarding the association between interleukin (IL) gene polymorphisms and HIV susceptibility. Medline, Scopus and the Web of Science databases were systematically searched, and a meta-analysis of case–control studies was conducted. Univariate and bivariate methods were used. The literature search identified 42 eligible studies involving 15,727 subjects. Evidence was obtained on eight single-nucleotide polymorphisms (SNPs): IL1A −889 C>T (rs1800587), IL1B +3953/4 C>T (rs1143634), IL4 −589/90 C>T (rs2243250), IL6 −174 G>C (rs1800795), IL10 −592 C>A (rs1800872), IL10−1082 A>G (rs1800896), IL12B −1188 A>C (rs3212227) and IL28B C>T (rs12979860). The IL1B +3953/4 C>T variant appears to increase the risk of HIV acquisition, under the assumption of a recessive genetic model (odds ratio (OR): 4.47, 95% CI: 2.35–8.52). The AA homozygotes of the IL10 -592 C>A SNP had an increased, marginally nonsignificant, risk (OR: 1.39, 95% CI: 0.97–2.01). It reached, however, significance in subanalyses (OR: 1.49, 95% CI: 1.04–2.12). Finally, the well-studied hepatitis C virus (HCV) infection IL28B (rs12979860) CT/TT genotypes were associated with a 27% decrease in HIV infection risk, especially in populations infected with HCV (OR: 0.73, 95% CI: 0.57–0.95). Interleukin signalling is perhaps important in HIV infection and some interleukin genetic variants may affect the risk of HIV acquisition. Approaches targeting specific genes and genomewide association studies should be conducted to decipher the effect of these polymorphisms.

    • Author Affiliations

       

      CHRISSA G TSIARA1 2 GEORGIOS K. NIKOLOPOULOS3 NIKI L. DIMOU4 KATERINA G. PANTAVOU3 PANTELIS G. BAGOS4 BENEDICTA MENSAH5 MICHAEL TALIAS6 GEORGIA G. BRALIOU4 DIMITRA PARASKEVA1 STEFANOS BONOVAS7 8 ANGELOS HATZAKIS2

      1. Hellenic Centre for Disease Control and Prevention, 15123 Athens, Greece
      2. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
      3. Medical School, University of Cyprus, 2029 Strovolos, Nicosia, Cyprus
      4. Department of Computer Science and Biomedical Informatics, University of Thessaly, 35100 Lamia, Greece
      5. Noguchi Memorial Institute for Medical Research, University of Ghana, P.O.Box LG 581 Accra, Ghana
      6. Healthcare Management Postgraduate Program, Open University of Cyprus, 2220 Nicosia, Cyprus
      7. Humanitas Clinical and Research Center, 20089 Milan, Italy
      8. Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy
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