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      https://www.ias.ac.in/article/fulltext/jgen/096/06/1041-1046

    • Keywords

       

      combined multivariate and collapsing method; myocardial infarction; exome sequencing

    • Abstract

       

      Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability inMI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of thesegenes with MI risk, and these associations have to be confirmed in other ethnic populations

    • Author Affiliations

       

      JI-YOUNG LEE1 2 SANGHOON MOON1 YUN KYOUNG KIM1 SANG-HAK LEE3 BOK-SOO LEE4 MIN-YOUNG PARK5 JEONG EUY PARK4 YANGSOO JANG3 BOK-GHEE HAN1

      1. Center for Genome Science,Korea National Institute ofHealth,KCDC,Cheongju-si,Chungcheongbuk-do 363-951,Korea
      2. Cardiovascular Research Institute and Cardiovascular Genome Center, Yonsei University Health System, Seoul 120-752, Korea
      3. Cardiology Division, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul 120-752, Korea
      4. Division of Cardiology, Samsung Medical Center, Seoul 135-710, Korea
      5. DNA link, Seoul 121-850, Korea
    • Dates

       
  • Journal of Genetics | News

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