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      https://www.ias.ac.in/article/fulltext/jgen/096/06/0993-1003

    • Keywords

       

      lactase; polymorphism; bone mineral density; fracture; meta-analysis

    • Abstract

       

      Anumber of studies have investigated the association of lactase (LCT,C/T-13910) gene polymorphismwith bonemineral density (BMD) and fracture risk, but previous results were inconclusive. In this study, a meta-analysis was performed to quantifythe association of LCT (C/T-13910) polymorphism with BMD and fracture risk. Eligible publications were searched in the PubMed, Web of Science, Embase databases, Google Scholar, Yahoo and Baidu. Pooled weighed mean difference (WMD) or odds ratio (OR) with their 95% confidence interval (CI) were calculated using a fixed-effects or random-effects model. A total of nine articles with8871 subjects were investigated in the presentmeta-analysis. Overall, the TT/TC genotypes of LCT 13910 C/T polymorphism showed significantly higher BMD than those with the CC genotype at femur neck (FN) (WMD = 0.011 g/cm2, 95% CI = 0.004–0.018, P = 0.003). Besides, LCT 13910 C/T polymorphism may decrease the risk of any site fractures (for TT versus TC+CC, OR = 0.813, 95% CI = 0.704–0.938, P = 0.005; for T allele versus C allele, OR = 0.885, 95% CI = 0.792–0.989, P = 0.032). However, there was no significant association of LCT 13910 C/T polymorphism with BMD at lumbar spine and risk of vertebral fractures under all genetic contrast models (all P values were >0.05). The meta-analysis suggests that there are significant effects of LCT 13910 C/T polymorphism on BMD and fracture risk. Large-scale studies with different ethnic populations will be needed to further investigate the possible race-specific effect of LCT 13910 C/T polymorphism on BMD and fracture risk

    • Author Affiliations

       

      YOUGEN WU1 2 YINGHUA LI1 YUNQING CUI1 YUNJIAO ZHOU1 QINGQING QIAN2 YANG HONG1 2 3

      1. Central Laboratory, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, People’s Republic of China
      2. National Institute of Clinical Research, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, People’s Republic of China
      3. Department ofOsteology, The Fifth People’sHospital of Shanghai, Fudan University, Shanghai 200240, People’sRepublic of China
    • Dates

       
  • Journal of Genetics | News

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