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      https://www.ias.ac.in/article/fulltext/jgen/096/02/0319-0325

    • Keywords

       

      goat PRNP gene; scrapie incidence; genetic resistance; environment; native breeds.

    • Abstract

       

      Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases affecting humans and animals, and scrapie in small ruminants is considered the archetype of TSEs. Derivata di Siria is a native dairy goat of Sicily (south Italy), which is related to Syrian goat breeds. Scrapie disease is considered endemic in Sicily since 1997, following the administration of an infected vaccine.Derivata di Siria goatswere involved in six of 66 scrapie-infected flocks in Sicily. Prion protein gene (PRNP) analysis revealed that none of the scrapie cases carried the p.Gln222Lys variant. Sequencing of PRNP in this goat population showed a high frequency (15%) of p.Gln222Lys variant confirming itsassociation with scrapie resistance. PRNP polymorphisms were also analysed in the population of Pantelleria, a small Sicilian Island, where scrapie has never been reported. The native goat breed ‘Pantesca’ was maintained up to almost80 years and the size of the sheep population on this island has historically been very low. Currently, a crossbreed goat population of 253 heads is present on the island. PRNP genotyping of Pantelleria goats showed genetic variation, withlow presence of wild-type goats and the lack of protective alleles. These data reinforce the association between PRNP polymorphisms in small ruminants and scrapie incidence.

    • Author Affiliations

       

      SERGIO MIGLIORE1 STEFANO AGNELLO1 SALVATORE D’AVOLA2 WILFRED GOLDMANN3 VINCENZO DI MARCO LO PRESTI1 MARIA VITALE1

      1. Istituto Zooprofilattico Sperimentale of Sicily, Adelmo Mirri, via Gino Marinuzzi 3, 90129 Palermo, Italy
      2. Public Veterinary Service, ASP 9 Trapani, 91017 Pantelleria, Italy
      3. The Roslin Institute, R(D)SVS University of Edinburgh Easter Bush, Midlothian EH259RG, Scotland, UK
    • Dates

       
  • Journal of Genetics | News

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