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      https://www.ias.ac.in/article/fulltext/jgen/095/04/0983-0989

    • Keywords

       

      OPG gene; polymorphism; single-nucleotide polymorphism; alcohol-induced osteonecrosis of femoral head.

    • Abstract

       

      Alcohol-induced osteonecrosis of femoral head (ONFH) is one of the most important pathogenesis of nontraumatic ONFH. However, its pathogenesis mechanism is still unknown. Osteoprotegerin (OPG) has been implicated in multiple functions including blocking osteoclast maturation, controlling vascular calcifications, promoting tumour growth and metastasis. This study is focussed on OPG gene polymorphisms associated with alcohol-induced ONFH. A total of 509 participants (209 patients and 300 normal individuals) were recruited, and we selected 13 single-nucleotide polymorphisms (SNPs) to evaluatethe association between genetic susceptibility variants and alcohol-induced ONFH by using the χ² test and genetic model analysis. Overall, OPG SNPs (rs1485286, rs1032128 and rs11573828) were confirmed the strongest increasing risks on alcohol-induced osteoporosis of femoral head in recessive model (rs1485286: OR, 1.71; 95% CI, 1.07–2.73; P = 0.025 for T/T); (rs1032128: OR, 1.73; 95% CI, 1.08–2.77; P = 0.022 for G/G); (rs11573828: OR, 3.89; 95% CI, 1.02–14.85; P = 0.033 for T/T). SNP rs11573856 was considered as a protective effect to the occurrence of alcohol-induced ONFH, while adjusted for age and gender in dominant and log-additive models (rs11573856: adjusted OR, 0.60; 95% CI, 0.37–0.96; P = 0.033 for G/A–A/A); (rs11573856: adjusted OR, 0.63; 95% CI, 0.41–0.96; P = 0.042). We conclude that OPG gene polymorphisms were associated with the occurrence of alcohol-induced ONFH.

    • Author Affiliations

       

      YIZHOU LI1 YONGCHANG GUO2 QUANJIAN WANG2 YONGRI OUYANG3 YUJU CAO2 TIANBO JIN3 4 JIANZHONG WANG1

      1. Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, People’s Republic of China
      2. Zhengzhou TCM Traumatology Hospital, Zhengzhou, Henan 450016, People’s Republic of China
      3. National Engineering Research Center for Miniaturized Detection System, Xi’an, Shanxi 710069, People’s Republic of China
      4. The College of Life Sciences, Northwest University, Xi’an, 710069, People’s Republic of China
    • Dates

       
  • Journal of Genetics | News

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