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      https://www.ias.ac.in/article/fulltext/jgen/095/03/0741-0750

    • Keywords

       

      osteopontin signalling pathway; nonalcoholic fatty liver disease; liver cirrhosis; hepatic cancer; acute hepatic failure.

    • Abstract

       

      To explore the relevance of OPN signalling pathway to the occurrence and development of nonalcoholic fatty liver disease (NAFLD), liver cirrhosis (LC), hepatic cancer (HC) and acute hepatic failure (AHF) at transcriptional level, Rat Genome 230 2.0 Array was used to detect expression profiles of OPN signalling pathway-related genes in four kinds of liver diseases. The results showed that 23, 33, 59 and 74 genes were significantly changed in the above four kinds of liver diseases, respectively. H-clustering analysis showed that the expression profiles of OPN signalling-related genes were notably different in four kinds of liver diseases. Subsequently, a total of above-mentioned 147 genes were categorized into four clusters by k-means according to the similarity of gene expression, and expression analysis systematic explorer (EASE) functional enrichment analysis revealed that OPN signalling pathway-related genes were involved in cell adhesion and migration, cell proliferation, apoptosis, stress and inflammatory reaction, etc. Finally, ingenuity pathway analysis (IPA) software was used to predict thefunctions of OPN signalling-related genes, and the results indicated that the activities of ROS production, cell adhesion and migration, cell proliferation were remarkably increased, while that of apoptosis, stress and inflammatory reaction were reduced in four kinds of liver diseases. In summary, the above physiological activities changed more obviously in LC, HC and AHF than in NAFLD

    • Author Affiliations

       

      GAIPING WANG1 2 SHASHA CHEN1 2 CONGCONG ZHAO1 2 XIAOFANG LI1 2 WEIMING ZHAO1 2 JING YANG1 2 CUIFANG CHANG2 CUNSHUAN XU2

      1. College of Life Science, Henan Normal University, Xinxiang 453007, Henan, People’s Republic of China
      2. State Key Laboratory Cultivation Base for Cell Differentiation Regulation, Henan Normal University, Xinxiang, People’s Republic of China
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