• Association of a common rs9939609 variant in the fat mass and obesity-associated (FTO) gene with obesity and metabolic phenotypes in a Taiwanese population: a replication study

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    • Keywords

       

      body mass index; FTO gene; metabolic phenotypes; obesity; single-nucleotide polymorphism

    • Abstract

       

      It is a key challenge to conduct reproducibility in genetic research, especially association studies in obesity. While susceptibility of a single-nucleotide polymorphism (SNP), rs9939609, in the fat mass and obesity-associated (FTO) gene to obesity has been reported in various populations, data from Asians is less conclusive. This replication study was carried out to test whether theFTO rs9939609 SNP is a predictive factor for obesity and obesity-related metabolic traits in a Taiwanese population. A total of 1188 Taiwanese subjects were recruited for this study. The FTO rs9939609 SNP was genotyped by theTaqman assay. Obesity-related metabolic traits such as triglyceride, waist circumference, systolic and diastolic blood pressure, total cholesterol, creatinine, alanine aminotransferase and fasting glucose were measured. Our data revealed that the FTO rs9939609 SNP exhibited a significant association with obesity (BMI

      >=30 kg/m ²) among the subjects ( P=0.026). However, the FTO rs9939609 SNP did not exhibit any significant association with obesity-related metabolic traits among the subjects. Our results indicated that the FTO rs9939609 SNP may be linked with the risk of obesity in Taiwanese subject

    • Author Affiliations

       

      TUN-JEN HSIAO1 LIN EUGENE2 3

      1. College of Public Health and Nutrition, Taipei Medical University, Taipei 11031, Taiwan
      2. Vita Genomics, Inc., 7 Fl., No. 6, Sec. 1, Jung-Shing Road, Wugu Shiang, Taipei 24872, Taiwan
      3. nstitute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan
    • Dates

       
  • Journal of Genetics | News

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