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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jgen/095/01/0151-0156

    • Keywords

       

      single-nucleotide polymorphism; VEGF-A; chronic obstructive pulmonary disease.

    • Abstract

       

      In this study, we examined and validated how common variants contribute to susceptibility to chronic obstructive pulmonarydisease (COPD) in the Han Chinese population. Here, we genotyped 18 nucleotide polymorphisms and evaluated their associationwith COPD using chi-square test and genetic model analysis (246 COPD patients and 350 controls), and found threeSNPs that might cause a predisposition to COPD. Both rs3025030 and rs3025033 are located on chromosome 6 in VEGF-A.We found one risk allele ‘C’ from rs3025030 and another ‘G’ from rs3025033 using the log-additive model (OR 1.40; 95% CI1.05–5.96; P = 0.022), (OR 1.38; 95% CI 1.03–1.84; P = 0.03). We also found another risk allele ‘A’ of rs9296092 in generegion ZBTB9-BAK1 by the allele model (OR 2.63; 95% CI 1.27–5.45; P = 0.0078), (adjusted OR 3.53; 95% CI 1.12–11.11; P = 0.031).We found a risk haplotype ‘CG’ associated with the risk of COPD (OR 1.39; 95% CI 1.04–1.86; P = 0.028). Ourresults when compared with previous studies showed significant association between VEGF-A polymorphism and COPD. Wealso identified rs9296092 as a risk factor for COPD.

    • Author Affiliations

       

      YIPENG DING1 HUAN NIU1 YIZHOU LI2 PING HE1 QUANNI LI1 YANHONG Ouyang1 MIN LI1 ZHIGAO HU1 YOUQING ZHONG3 PEI SUN1 TIANBO JIN4 5

      1. Department of Emergency, People’s Hospital of Hainan Province, Haikou, Hainan 570311, People’s Republic of China
      2. Department of Orthopedics and Traumatology, The Second Affiliated Hospital of Inner Mongolia University, Huhehot 010030, Inner Mongolia, People’s Republic of China
      3. Department of Respiratory Medicine, The Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, People’s Republic of China
      4. School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, People’s Republic of China
      5. National Engineering Research Center for Miniaturized Detection Systems, Xi’an, Shanxi 710069, People’s Republic of China

    • Dates

       
      Published
      10 March 2016
      Manuscript received
      6 May 2015
      Manuscript revised
      27 July 2015
      Accepted
      13 August 2015
      Unedited version published online
      17 August 2015
      Final version published online
      4 March 2016

  • Journal of Genetics | News

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      Posted on July 25, 2019

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