Polymorphisms in VEGF-A are associated with COPD risk in the Chinese population from Hainan province
YIPENG DING HUAN NIU YIZHOU LI PING HE QUANNI LI YANHONG Ouyang MIN LI ZHIGAO HU YOUQING ZHONG PEI SUN TIANBO JIN
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In this study, we examined and validated how common variants contribute to susceptibility to chronic obstructive pulmonarydisease (COPD) in the Han Chinese population. Here, we genotyped 18 nucleotide polymorphisms and evaluated their associationwith COPD using chi-square test and genetic model analysis (246 COPD patients and 350 controls), and found threeSNPs that might cause a predisposition to COPD. Both rs3025030 and rs3025033 are located on chromosome 6 in VEGF-A.We found one risk allele ‘C’ from rs3025030 and another ‘G’ from rs3025033 using the log-additive model (OR 1.40; 95% CI1.05–5.96; P = 0.022), (OR 1.38; 95% CI 1.03–1.84; P = 0.03). We also found another risk allele ‘A’ of rs9296092 in generegion ZBTB9-BAK1 by the allele model (OR 2.63; 95% CI 1.27–5.45; P = 0.0078), (adjusted OR 3.53; 95% CI 1.12–11.11; P = 0.031).We found a risk haplotype ‘CG’ associated with the risk of COPD (OR 1.39; 95% CI 1.04–1.86; P = 0.028). Ourresults when compared with previous studies showed significant association between VEGF-A polymorphism and COPD. Wealso identified rs9296092 as a risk factor for COPD.
YIPENG DING1 HUAN NIU1 YIZHOU LI2 PING HE1 QUANNI LI1 YANHONG Ouyang1 MIN LI1 ZHIGAO HU1 YOUQING ZHONG3 PEI SUN1 TIANBO JIN4 5
Volume 102, 2023
Continuous Article Publishing mode
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