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      https://www.ias.ac.in/article/fulltext/jgen/095/01/0079-0087

    • Keywords

       

      growth hormone; single-nucleotide polymorphisms; linkage disequilibrium analysis; body size.

    • Abstract

       

      Growth hormone (GH) has been considered as a candidate gene for growth and body size in pigs. In this study, polymorphismsof the GH1 gene were evaluated for associations with body size traits in 190 pig individuals. Seventeen single-nucleotidepolymorphisms (SNP$_{s}$) were identified in GH1 gene of the large pig breeds and miniature pig breeds using direct sequencingand genotyped by allele-specific PCR approach. Notably, six (g.237A>G, g.283T>C, g.309A>G, g.318A>G, g.540A>G andg.544A>G) of them were significantly associated with body size, of which three loci (g.283T>C, g.309A>G, g.318A>G)located in the signal-peptide coding region of GH1 gene compose a CGG haplotype for large pigs and TAA haplotype forminiature pigs (P<0.001), two loci (g.540A>G and g.544A>G) located in the second intron of GH1 gene compose a GGhaplotype for large pigs and AA haplotype for miniature pigs (P <0.001). Our results demonstrate that these SNP$_{s}$ in GH1gene are associated with the body size of pigs providing genetic basis for pig breeding with the improved economic benefits.

    • Author Affiliations

       

      YUNYUN CHENG1 LIU SONGCAI1 2 DAN SU1 CHAO LU1 ZHANG XIN1 QINGYAN WU1 SIMING LI1 HAOYU FU1 HAO YU1

      1. College of Animal Science, Jilin University, 5333 Xi’an Road, Changchun, Jilin 130062, People’s Republic of China
      2. Five-Star Animal Health Pharmaceutical Factory of Jilian Province, 5333 Xi’an Road, Changchun, Jilin 130062, People’s Republic of China
    • Dates

       
  • Journal of Genetics | News

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