Case–control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians
The rennin–angiotensin–aldosterone system (RAAS) is a critical pathway in regulating blood pressure and salt/water homeostasis,possessing an intimate relationship with the development of systemic artery hypertension (SAH). Once hypertensionis considered a risk factor for coronary artery disease (CAD), the RAAS is also related to this pathology. This investigationaimed to analyse if the frequencies of AGT M235T (rs699) and ACE I/D (rs4646994) polymorphisms are associated with CADand SAH in African-Brazilians and Caucasian-Brazilians. In this study we analysed 714 subjects who underwent coronaryangiography to detect obstructive lesions and CAD, as well as blood pressure measurement and SAH, grouped accordingto ethnicity: 266 African-Brazilians and 448 Caucasian-Brazilians. Among CAD and SAH cases and controls, the genotypeand allele frequencies of ACE I/D polymorphism were similar in both ethnic groups. The AGT 235TT genotype and 235Tallele frequencies were higher in SAH cases (32%, 54.7%) versus controls in Caucasian-Brazilians (19.8%, 46.4%; P =0.038, P = 0.031, respectively). The AGT 235TT (OR = 1.8; P = 0.028) demonstrated to be an independent factor riskin a multivariate logistic regression increasing SAH risk in Caucasians but not in African-Brazilians. In summary, AGTM235T polymorphism was associated with SAH risk in Caucasian-Brazilians, and no association was detected with CAD.No association was also observed in ACE I/D polymorphism either in CAD or SAH in African-Brazilians and Caucasian-Brazilians.
Volume 100, 2021
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