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      https://www.ias.ac.in/article/fulltext/jgen/095/01/0063-0069

    • Keywords

       

      atherosclerosis; hypertension; rennin–angiotensin–aldosterone system; single-nucleotide polymorphism; ethnicity.

    • Abstract

       

      The rennin–angiotensin–aldosterone system (RAAS) is a critical pathway in regulating blood pressure and salt/water homeostasis,possessing an intimate relationship with the development of systemic artery hypertension (SAH). Once hypertensionis considered a risk factor for coronary artery disease (CAD), the RAAS is also related to this pathology. This investigationaimed to analyse if the frequencies of AGT M235T (rs699) and ACE I/D (rs4646994) polymorphisms are associated with CADand SAH in African-Brazilians and Caucasian-Brazilians. In this study we analysed 714 subjects who underwent coronaryangiography to detect obstructive lesions and CAD, as well as blood pressure measurement and SAH, grouped accordingto ethnicity: 266 African-Brazilians and 448 Caucasian-Brazilians. Among CAD and SAH cases and controls, the genotypeand allele frequencies of ACE I/D polymorphism were similar in both ethnic groups. The AGT 235TT genotype and 235Tallele frequencies were higher in SAH cases (32%, 54.7%) versus controls in Caucasian-Brazilians (19.8%, 46.4%; P =0.038, P = 0.031, respectively). The AGT 235TT (OR = 1.8; P = 0.028) demonstrated to be an independent factor riskin a multivariate logistic regression increasing SAH risk in Caucasians but not in African-Brazilians. In summary, AGTM235T polymorphism was associated with SAH risk in Caucasian-Brazilians, and no association was detected with CAD.No association was also observed in ACE I/D polymorphism either in CAD or SAH in African-Brazilians and Caucasian-Brazilians.

    • Author Affiliations

       

      BONFIM-SILVA RICARDO1 2 OLIVEIRA GUIMARÃES LARISSA1 2 SANTOS JANDSON SOUZA1 3 JAQUELINE FAGUNDES PEREIRA1 4 ANA ANGÉLICA LEAL BARBOSA1 RIOS DOMINGOS LAZARO SOUZA1 5

      1. Department of Biological Sciences, University of Southwest of Bahia, Campus Jequié, Rua José Moreira Sobrinho, s/n, Jequiezinho, 45200-000, Jequié, Bahia, Brazil
      2. Department of Genetics, Medical School of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, 14049-900, Ribeirão Preto, São Paulo, Brazil
      3. Department of Biological Sciences and Health, Federal University of Sergipe, Av. Marechal Rondon, s/n, Jardim Rosa Elze, 49100-000, Aracajú, Sergipe, Brazil
      4. Department of Biotechnology, State University of Feira de Santana, Campus Universitário, Avenida Transnordestina, s/n, 44036-900, Feira de Santana, Bahia, Brazil
      5. Department of Life Sciences, University of the State of Bahia, Campus I, Rua Silveira Martins, 2555, 41195-001, Salvador, Bahia, Brazil
    • Dates

       
  • Journal of Genetics | News

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