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      https://www.ias.ac.in/article/fulltext/jgen/094/04/0591-0599

    • Keywords

       

      X chromosome; X inactivation; escape from X inactivation.

    • Abstract

       

      X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.

    • Author Affiliations

       

      Christine M. Disteche1 2 Joel B. Berletch1

      1. Department of Pathology, University of Washington, Seattle, WA 98195, USA
      2. Department of Medicine, University of Washington, Seattle, WA 98195, USA
    • Dates

       
  • Journal of Genetics | News

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