Click here to view fulltext PDF

Permanent link:
https://www.ias.ac.in/article/fulltext/jgen/094/03/0539-0549

genes; coronary artery disease; genetic epidemiology; single-nucleotide polymorphism; Asian Indians.

Coronary artery disease (CAD) has emerged as a major cause of morbidity and mortality worldwide. Recent findings on the role of genetic factors in the aetiopathology of CAD have implicated novel genes and variants in addition to those involved in lipid and lipoprotein metabolism. However, our present knowledge is limited due to lack of clarity on their exact identity and the quantum of impact on disease susceptibility, and incident risk. It is a matter of great interest to understand the role of genetic factors in ethnic populations that have a strong underlying predisposition to CAD such as the South Asian populations, particularly among Asian Indians living in India and abroad. Although, a number of isolated studies do implicate certain gene polymorphisms towards enhanced disease susceptibility, the available data remains scanty and inconclusive as they have not been validated in large, prospective cohorts. The present review aims to consolidate the available literature on the genetics of CAD in Asian Indians and seeks to provide insights on the concerns that need to be addressed in future studies to generate information having clinical value.

Shanker Jayashree¹ Maitra Arindam² Kakkar V. Vijay¹

1. Functional Genomics Thrombosis Research Institute, Bengaluru 560 099, India
2. National Institute of Biomedical Genomics, Kalyani 741 251, India

Published

September 2015

Manuscript received

10 September 2014

Manuscript revised

1 March 2015

Accepted

11 March 2015

Unedited version published online

13 March 2015

Early published

27 August 2015