• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jgen/093/03/0879-0892

    • Keywords

       

      depression; brain-derived neurotropic factor; 5-HT; 5-HTTLPR; neurogenesis; synaptic plasticity

    • Abstract

       

      Joyousness or sadness is normal reaction to state of life. If any of these lead to certain semi-permanent changes in daily life, then it is termed as mental disorder. Depression is one of the mental disorders with a state of low mood and aversion to activities that exerts a negative effect on a person’s thoughts and behaviour. Adolescent group is probably the world’s largest active group of people, who are getting prone to this state of mind leading to their diminished mental and physical abilities. Depression is closely linked to stress and thus a chronic stressful life can increase the risk of depression. Depression is a complex disease having both genetic and environmental components as contributing factors. In this study an attempt has been made to put forward the understanding of the known genes and their functional relationships with depression and stress with special reference to BDNF and 5-HTTLPR. Analysis of common genetic variants associated with depression, especially in the members of a family who had a previous history, might help in identifying the individuals at risk prior to the onset of depression.

    • Author Affiliations

       

      Madhumita Roy1 Madhu G. Tapadia1 Shobhna Joshi2 Biplob Koch1

      1. Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
      2. Department of Psychology, Banaras Hindu University, Varanasi 221 005, India
    • Dates

       
  • Journal of Genetics | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.