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      https://www.ias.ac.in/article/fulltext/jgen/093/03/0799-0808

    • Keywords

       

      11𝛽HSD2; ATR1; CYP11B2; gene polymorphism; hypertension; risk factors.

    • Abstract

       

      Essential hypertension which accounts 90–95% of the total hypertension cases is affected by both genetic and environmental factors. This study was undertaken to investigate the association of aldosterone synthase C-344T, angiotensin II type I receptor A1166C and 11-𝛽 hydroxysteroid dehydrogenase type 2 G534A polymorphisms with essential hypertension in the population of Odisha, India. A total of 246 hypertensive subjects (males, 159; females, 87) and 274 normal healthy individuals (males, 158; females, 116) were enrolled in this study based on the inclusion and exclusion criteria. Analysis of genetic and biochemical data revealed that in this population the CT and TT genotypes of aldosterone synthase C-344T polymorphism, frequency of alcohol consumption and aldosterone levels were significantly high among the total as well as male hypertensives, while the AC and CC genotypes of angiotensin II type I receptor A1166C polymorphism were significantly high among the total as well as female hypertensives. High density lipoprotein levels were higher in male hypertensives.

    • Author Affiliations

       

      Manisha Patnaik1 2 Pallabi Pati1 Surendra N. Swain3 Manoj K. Mohapatra4 Bhagirathi Dwibedi5 Shantanu K. Kar5 Manoranjan Ranjit1

      1. Department of Molecular Biology, Regional Medical Research Centre, Chandrasekharpur, Bhubaneswar 751 023, India
      2. School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar 751 024, India
      3. Department of Medicine, Capital Hospital, Bhubaneswar 751 001, India
      4. Department of Medicine, VSS Medical College, Burla 768 017, India
      5. Clinical Division, Regional Medical Research Centre, Chandrasekharpur, Bhubaneswar 751 023, India
    • Dates

       
  • Journal of Genetics | News

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