• Fulltext


        Click here to view fulltext PDF

      Permanent link:

    • Keywords


      Artemisia; ADS promoter; cis-elements; artemisinin.

    • Abstract


      Artemisinin is the most effective antimalarial drug that is derived from Artemisia annua. Amorpha-4,11-diene synthase (ADS) controls the first committed step in artemisinin biosynthesis. The ADS gene expression is regulated by transcription factors which bind to the cis-acting elements on the ADS promoter and are probably responsible for the ADS gene expression difference in the Artemisia species. To identify the elements that are significantly involved in ADS gene expression, the ADS gene promoter of the seven Artemisia species was isolated and comparative analysis was performed on the ADS promoter sequences of these species. Results revealed that some of the cis-elements were unique or in terms of number were more in the high artemisinin producer species, A. annua, than the other species. We have reported that the light-responsive elements, W-box, CAAT-box, 5′-UTR py-rich stretch, TATA-box sequence and tandem repeat sequences have been identified as important factors in the increased expression of ADS gene.

    • Author Affiliations


      Mojtaba Ranjbar1 2 Mohammad Reza Naghavi1 Hoshang Alizadeh1

      1. Agronomy and Plant Breeding Department, College of Agriculture, University of Tehran, Karaj, 31587-11167, Iran
      2. Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, 46168-49767, Iran
    • Dates

  • Journal of Genetics | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.