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      https://www.ias.ac.in/article/fulltext/jgen/092/03/0403-0412

    • Keywords

       

      genome signature; DRAP; HIV-1; chaos game representation.

    • Abstract

       

      Dinucleotide usage is known to vary in the genomes of organisms. The dinucleotide usage profiles or genome signatures are similar for sequence samples taken from the same genome, but are different for taxonomically distant species. This concept of genome signatures has been used to study several organisms including viruses, to elucidate the signatures of evolutionary processes at the genome level. Genome signatures assume greater importance in the case of host–pathogen interactions, where molecular interactions between the two species take place continuously, and can influence their genomic composition. In this study, analyses of whole genome sequences of the HIV-1 subtype B, a retrovirus that caused global pandemic of AIDS, have been carried out to analyse the variation in genome signatures of the virus from 1983 to 2007.We show statistically significant temporal variations in some dinucleotide patterns highlighting the selective evolution of the dinucleotide profiles of HIV-1 subtype B, possibly a consequence of host specific selection.

    • Author Affiliations

       

      Aridaman Pandit1 2 Jyothirmayi Vadlamudi1 Somdatta Sinha3

      1. Centre for Cellular and Molecular Biology (CSIR), Hyderabad 500 007, India
      2. Theoretical Biology and Bioinformatics, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands
      3. Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, SAS Nagar, Manauli 140 306, India
    • Dates

       
  • Journal of Genetics | News

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