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    • Keywords


      THR; polymorphisms; mutation; disease susceptibility.

    • Abstract


      Thyroid hormone receptors (TR) are prototypes of nuclear transcription factors that regulate the expression of target genes. These receptors play an important role in many physiological processes. Moreover, a dysfunction of these proteins is often implicated in several human diseases and malignancies. Here we report genetic variations and alterations of the TRs that have been described in the literature as well as their potential role in the development of some human diseases including cancers. The functional effects of some mutations and polymorphisms in TRs on disease susceptibility, especially on cancer risk, are now established. Therefore, further investigations are needed in order to use these receptors as therapeutic targets or as biological markers to decide on appropriate forms of treatment.

    • Author Affiliations


      Maha Rebaï1 Imen Kallel1 Ahmed Rebaï1

      1. Molecular and Cellular Diagnosis Processes, Centre of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour, P. O. Box 1177, 3018 Sfax, Tunisia
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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