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      https://www.ias.ac.in/article/fulltext/jgen/091/02/0119-0128

    • Keywords

       

      arthritis; interleukin-1 receptor antagonist; microarray; mouse; QTL; SNP.

    • Abstract

       

      Rheumatoid arthritis is a heterogeneous disease with clinical and biological polymorphisms. IL-1RN is a protein that binds to interleukin-1 (IL-1) receptors and inhibits the binding of IL-1-alpha and IL-1-beta. IL-1RN levels are elevated in the blood of patients with a variety of infectious, immune, and traumatic conditions. Balb/c mice deficient in IL-1ra (mouse gene of IL-1RN) develop spontaneous autoimmune arthritis while DBA/1 mice deficient in IL-1ra do not. Previously, we identified a major QTL that regulates the susceptibility to arthritis in Balb/c mice with IL-1ra deficiency. In this study, we found that the QTL may contain two peaks that are regulated by two sets of candidate genes. By haplotype analysis, the total genomic regions of candidate genes were reduced from about 19 Mbp to approximately 9 Mbp. The total number of candidate genes was reduced from 208 to 21.

    • Author Affiliations

       

      Yanhong Cao1 2 Jifei Zhang3 Yan Jiao2 Jian Yan4 Feng Jiao2 Xiaoyun Liu2 Robert W. Williams5 Karen A. Hasty2 John M. Stuart4 Weikuan Gu2

      1. Institute of Kaschin-Beck Disease, Center for Endemic Disease Control, Centers for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, People’s Republic of China
      2. Department of Orthopaedic Surgery, Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
      3. Mudanjiang Medical College, Mudanjiang, 157001, People’s Republic of China
      4. Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
      5. Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
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    • Supplementary Material

       
  • Journal of Genetics | News

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