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      https://www.ias.ac.in/article/fulltext/jgen/089/04/0417-0423

    • Keywords

       

      population stratification; ancestry informative markers (AIMs); race; ethnicity; genetic epidemiology; forensic genetics; Hispanics.

    • Abstract

       

      Self-reported race/ethnicity is frequently used in epidemiological studies to assess an individual’s background origin. However, in admixed populations such as Hispanic, self-reported race/ethnicity may not accurately represent them genetically because they are admixed with European, African and Native American ancestry. We estimated the proportions of genetic admixture in an ethnically diverse population of 396 mothers and 188 of their children with 35 ancestry informative markers (AIMs) using the STRUCTURE version 2.2 program. The majority of the markers showed significant deviation from Hardy–Weinberg equilibrium in our study population. In mothers self-identified as Black and White, the imputed ancestry proportions were 77.6% African and 75.1% European respectively, while the racial composition among self-identified Hispanics was 29.2% European, 26.0% African, and 44.8% Native American.We also investigated the utility of AIMs by showing the improved fitness of models in paraoxanase-1 genotype–phenotype associations after incorporating AIMs; however, the improvement was moderate at best. In summary, a minimal set of 35 AIMs is sufficient to detect population stratification and estimate the proportion of individual genetic admixture; however, the utility of these markers remains questionable.

    • Author Affiliations

       

      Yin Leng Lee1 2 Susan Teitelbaum1 Mary S. Wolff1 James G. Wetmur2 3 Jia Chen1 4 5

      1. Departments of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
      2. Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
      3. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
      4. Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
      5. Department of Oncological Science, Mount Sinai School of Medicine, New York, NY 10029, USA
    • Dates

       
  • Journal of Genetics | News

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