• New Y chromosomes and early stages of sex chromosome differentiation: sex determination in Megaselia

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      https://www.ias.ac.in/article/fulltext/jgen/089/03/0307-0313

    • Keywords

       

      sex chromosome turnover; Sex-lethal; doublesex; Maleness; sex determination; Diptera; Megaselia.

    • Abstract

       

      The phorid fly Megaselia scalaris is a laboratory model for the turnover and early differentiation of sex chromosomes. Isolates from the field have an XY sex-determining mechanism with chromosome pair 2 acting as X and Y chromosomes. The sex chromosomes are homomorphic but display early signs of sex chromosome differentiation: a low level of molecular differences between X and Y. The male-determining function $(M)$, maps to the distal part of the Y chromosome’s short arm. In laboratory cultures, new Y chromosomes with no signs of a molecular differentiation arise at a low rate, probably by transposition of 𝑀 to these chromosomes. Downstream of the primary signal, the homologue of the Drosophila doublesex (dsx) is part of the sex-determining pathway while Sex-lethal (Sxl), though structurally conserved, is not.

    • Author Affiliations

       

      Walther Traut1

      1. Institut für Biologie, Zentrum für medizinische Struktur- und Zellbiologie, Universität Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
    • Dates

       
  • Journal of Genetics | News

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