• The role of the Drosophila LAMMER protein kinase DOA in somatic sex determination

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    • Keywords


      phosphorylation; alternative splicing; SR proteins; sex determination.

    • Abstract


      DOA kinase, the Drosophila member of the LAMMER/Clk protein kinase family, phosphorylates SR and SR-like proteins, including TRA, TRA2 and RBP1, which are responsible for the alternative splicing of transcripts encoding the key regulator of sex-specific expression in somatic cells of the fly, DOUBLESEX. Specific Doa alleles induce somatic female-to-male sex transformations, which can be enhanced when combined with mutations in loci encoding SR and SR-like proteins. The Doa locus encodes six different kinases, of which a 69-kDa isoform is expressed solely in females. Expression of this isoform is itself under the regulation of the somatic sex determination regulatory network, thus forming a putative positive autoregulatory loop which would reinforce the choice of the female cell-fate. We speculate that this loop is part of the evolutionary ancestral sex-determination machinery, based upon evidence demonstrating the existence of an autoregulatory loop involving TRA and TRA2 in several other insect species.

    • Author Affiliations


      Leonard Rabinow1 Marie-Laure Samson1

      1. Université Paris Sud 11, CNRS UMR 8195, Centre de Neurosciences de Paris Sud, Bâtiment 442 bis, 91405 Orsay Cedex, France
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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