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ocular angiogenesis; corneal neovascularization; retinal neovascularization; diabetic retinopathy; age-related macular degeneration; retinopathy of prematurity; VEGF; PEDF; Flt-1; Flk-1; endostatin; angiopoietin; erythropoietin; Tie2; inflammation; <

Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.

Yureeda Qazi¹ Surekha Maddula¹ Balamurali K. Ambati¹

1. Department of Ophthalmology, John Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, UT-84132, USA

Published

December 2009

Manuscript received

27 August 2009

Manuscript revised

22 October 2009

Accepted

26 October 2009

Early published

31 December 2009