• Molecular complexity of primary open angle glaucoma: current concepts

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      https://www.ias.ac.in/article/fulltext/jgen/088/04/0451-0467

    • Keywords

       

      glaucoma; POAG; neurodegeneration.

    • Abstract

       

      Glaucoma is a group of heterogeneous optic neuropathies with complex genetic basis. Among the three principle subtypes of glaucoma, primary open angle glaucoma (POAG) occurs most frequently. Till date, 25 loci have been found to be linked to POAG. However, only three underlying genes (Myocilin, Optineurin and WDR36) have been identified. In addition, at least 30 other genes have been reported to be associated with POAG. Despite strong genetic influence in POAG pathogenesis, only a small part of the disease can be explained in terms of genetic aberration. Current concepts of glaucoma pathogenesis suggest it to be a neurodegenerative disorder which is triggered by different factors including mechanical stress due to intra-ocular pressure, reduced blood flow to retina, reperfusion injury, oxidative stress, glutamate excitotoxicity, and aberrant immune response. Here we present a mechanistic overview of potential pathways and crosstalk between them operating in POAG pathogenesis.

    • Author Affiliations

       

      Kunal Ray1 Suddhasil Mookherjee1

      1. Molecular and Human Genetic Division, Indian Institute of Chemical Biology (a unit of CSIR), Kolkata 700 032, India
    • Dates

       
  • Journal of Genetics | News

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