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    • Keywords


      FLT3/ITD mutation; p53 tumor suppressor gene; NRAS gene; acute myeloid leukemia (AML); tetraploidy/near-tetraploidy; human genetics.

    • Abstract


      Patients with de novo acute myeloid leukemia (AML) and near-tetraploid or completely tetraploid karyotype at presentation are rare. We present four patients with near-tetraploidy/tetraploidy in a cohort of 426 consecutive AML patients (0.98%) in respect to their cytogenetic findings, immunophenotype pattern, response to chemotherapy, course of disease and molecular analyses including tyrosine kinase receptor FLT3 gene, NRAS gene, and tumour suppressor gene, p53. We have found FLT3/ITD mutation only in one patient among the four with near-tetraploidy. The main finding is that these patients had a variable clinical course, with two having a long period of remission (36 and 12 months) and two died, not having achieved remission.

    • Author Affiliations


      Vladimir Jurišić1 Sonja Povlović2 Nataša Čolović1 Vesna Djordjevic1 Vera Bunjevački3 Gradimir Janković1 Milica Čolović1

      1. Institute of Hematology, Medical School, 11000 Belgrade, Serbia
      2. Institute of Molecular Genetics and Genetic Engineering, Medical School, 11000 Belgrade, Serbia
      3. Institute of Biology, Medical School, 11000 Belgrade, Serbia
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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