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    • Keywords


      evolutionary history; mammals; somatostatin; tandem duplication.

    • Abstract


      Somatostatin and its receptors have a critical role in mammalian growth through their control pattern of secretion of growth hormone, but the evolutionary history of somatostatin and somatostatin receptors are ill defined. We used comparative whole genome analysis of Danio rerio, Carassius auratus, Xenopus tropicalis, Gallus gallus, Monodelphis domestica, Homo sapiens, Sus scrofa, Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Ovis aries, Equus caballus, Pan troglodytes and Macaca mulatto to identify somatostatin and somatostatin receptors in each species. To date, we have identified a minimum of two genes of somatostatin and five somatostatin receptor genes in mammalian species with variable forms. We established a clear evolutionary history of the somatostatin system and traced the origin of the somatostatin system to 395 million years ago (MYA), identifying critical steps in their evolution.

    • Author Affiliations


      Muhammad Moaeen-Ud-Din1 2 Li Guo Yang1

      1. China Education Ministry’s Key Laboratory of Animal Breeding, Genetics and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China
      2. Department of Livestock Production, University of Veterinary and Animal Sciences, Lahore 52000, Pakistan
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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