• The role of microRNAs (miRNA) in circadian rhythmicity

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      https://www.ias.ac.in/article/fulltext/jgen/087/05/0505-0511

    • Keywords

       

      circadian clock; chronobiology; microRNA (miRNA); posttranscriptional regulation

    • Abstract

       

      MicroRNA (miRNA) is a recently discovered new class of small RNA molecules that have a significant role in regulating gene and protein expression. These small RNAs (∼22 nt) bind to 3′ untranslated regions (3′UTRs) and induce degradation or repression of translation of their mRNA targets. Hundreds of miRNAs have been identified in various organisms and have been shown to play a significant role in development and normal cell functioning. Recently, a few studies have suggested that miRNAs may be an important regulators of circadian rhythmicity, providing a new dimension (posttranscriptional) of our understanding of biological clocks. Here, we describe the mechanisms of miRNA regulation, and recent studies attempting to identify clock miRNAs and their function in the circadian system.

    • Author Affiliations

       

      Mirko Pegoraro1 Eran Tauber1

      1. Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    • Dates

       
  • Journal of Genetics | News

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