• Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system

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      https://www.ias.ac.in/article/fulltext/jgen/087/05/0437-0446

    • Keywords

       

      Clock gene; suprachiasmatic nucleus (SCN); circadian rhythms; biological clocks; negative feedback loops; CLOCK; NPAS2.

    • Abstract

       

      A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.

    • Author Affiliations

       

      Jason P. Debruyne1

      1. Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 835 BRBII/III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    • Dates

       
  • Journal of Genetics | News

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      Posted on July 25, 2019

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