The rate of spontaneous mutation of a human gene
The rate of mutation at which the gene for haemophilia appears in the population of London is estimated at about once in 50,000 human life cycles. There are probably two distinct allelomorphs at the same locus, the milder type arising less frequently by mutation than the severe type.
I have to thank Dr Julia Bell and Dr C. V. Green for most generously placing at my disposal data collected on behalf of the Medical Research Council and the Research Committee of the American Medical Association.
Volume 98, 2019
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