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    • Keywords


      microsatellite markers; polymorphism; allele frequency; population studies; disequilibrium

    • Abstract


      Genotypes of 103 short tandem repeat (STR) markers distributed at an average of 40 cM intervals throughout the genome were determined for 40 individuals from the village of BirEl Hfai (BEH). This village of approximately 31.000 individuals is localized in the south-west of Tunisia. The allele frequency distributions in BEH were compared with those obtained for individuals in the CEPH (Centre d’Etude du Polymorphisme Humain) data using a Kolmo-gorov-Smirnov two-sample test. Fourteen out of the 103 markers (13.2%) showed significant differences (P<0.05) in distribution between the two populations. Population heterogeneity in BEH was indicated by an excess of observed homozygosity deviations from Hardy-Weinberg equilibrium at 3 loci (P<0.0005). No evidence for genotypic disequilibrium was found for any of the marker pairs. This demonstrated that in spite of a high inbreeding level in the population, few markers showed evidence for a different pattern of allelic distribution compared to CEPH.

    • Author Affiliations


      Abdellatif Maalej1 Ahmed Rebai2 Adnen Ayadi1 Jomaa Jouida3 Hafedh Makni1 Hammadi Ayadi1

      1. Faculté de Médecine, Laboratoire de Génétique Moléculaire Humaine, Avenue Majida Boulila, Sfax - 3029, Tunisia
      2. Unité de bioinformatique, Centre de Biotechnologie de Sfax, B.P.‘K’, 3038, Sfax, Tunisia
      3. Dispensaire de Bir ElHfai, Sidi Bouzid, Tunisia
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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