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    • Keywords


      PDIK1L ; protein kinase; human; expression

    • Abstract


      We isolated a 4301-bp cDNA from a human foetal brain cDNA library by high-throughput cDNA sequencing. It encodes a protein of 341 amino acids, which shows 69% identity with the human kinase CLIK1 (AAL99353), which was suggested to be the CLP-36 interacting kinase. Bioinformatics analysis suggests that the putative kinase may interact with PDZ and LIM domain proteins. Therefore the protein and its cDNA were named ’PDLIM1 interacting kinase 1 like’ (PDIK1L; nomenclature approved by the HUGO Gene Nomenclature Committee). Ensembl Genome Browser locatedPDIK1L to human chromosome 1p35.3. It spans about 13.7 kb and consists of four exons and three introns. Multiple-tissue cDNA panel PCR revealed that the gene is expressed widely in human tissues: liver, kidney, pancreas, spleen, thymus and prostate. The protein appears to be localized to the nucleus.

    • Author Affiliations


      Lingchen Guo1 Chaoneng Ji1 Shaohua Gu1 Kang Ying1 Haipeng Cheng1 Xiaoghua Ni1 Jianping Liu1 Yi Xie1 Yumin Mao1

      1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai - 200433, People’s Republic of China
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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