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    • A comparison of two popular statistical methods for estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences

      Analabha Basu Partha P. Majumder

      Volume 82 Issue 1-2 April 2003 pp 7-12

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jgen/082/01-02/0007-0012

    • Keywords

       

      coalescence; Monte-Carlo simulation; evolution

    • Abstract

       

      We have compared two statistical methods of estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences, which have been proposed by Templeton (1993) and Bandeltet al. (1995). Monte-Carlo simulations were used for generating DNA sequence data. Different evolutionary scenarios were simulated and the estimation procedures were evaluated. We have found that for both methods (i) the estimates are insensitive to demographic parameters and (ii) the standard deviations of the estimates are too high for these methods to be reliably used in practice.

    • Author Affiliations

       

      Analabha Basu1 Partha P. Majumder1

      1. Anthropology & Human Genetics Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata - 700 108, India

    • Dates

       
      Published
      8 April 2003
      Manuscript received
      29 April 2003

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