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MATH2 ; transcription factor; bHLH; novel human gene

We report cloning and some features of a novel human gene,MATH2, which encodes a protein of 337 amino acid residues with a basic helix-loop-helix domain and exhibits 98% similarity to mouseMath2. Results of Northern blot analysis revealed two transcripts of theMATH2 gene of 1.7 kb and 2.4 kb in human brain. We localizedMATH2 to chromosome 7 at 7p14-15 by matching with the Human Genome Sequence Database. HumanMATH2 and mouseMath2 may have the same functions in the nervous system.

Lingchen Guo¹ Min Jiang¹ Yushu Ma¹ Haipeng Cheng¹ Xiaohua Ni¹ Yangsheng Jin² Yi Xie¹ Yumin Mao¹

1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai - 200433, People’s Republic of China
2. United Gene Holdings, Ltd, Shanghai - 200092, People’s Republic of China

Published

April 2002

Manuscript received

14 December 2001