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    • Keywords


      HIV-1 resistance polymorphism; chemokine receptor; stromal-derived factor-1; Andhra Pradesh; AIDS

    • Abstract


      Polymorphic allelic variants of chemokine receptors CCR2 and CCR5, as well as of stromal-derived factor-1 SDF-1, the ligand for the chemokine receptor CXCR4, are known to have protective effects against HIV-1 infection and to be involved with delay in disease progression. We have studied the DNA polymorphisms at the loci that encode these proteins in 525 healthy individuals without any history of HIV-1 infection from 11 diverse populations of Andhra Pradesh, South India. The two protective allelesSDF-1-3′A andCCR2-64I at the SDF-1 and CCR2 loci, respectively, are present in all populations studied, although their frequencies differ considerably across populations (from 17% to 35% for theSDF-1-3′A allele, and from 3% to 17% forCCR2-64I). In contrast theCCR5-δ32 allele is observed only in three populations (Yamani, Pathan and Kamma), all in low frequencies (i.e. 1% to 3%). The mean number of mutant alleles (for the three loci together) carried by each individual varies from 0.475 (in Vizag Brahmins) to 0.959 (in Bohra Muslims). The estimated relative hazard values for the populations, computed from the three-locus genotype data, are comparable to those from Africa and Southeast Asia, where AIDS is known to be widespread.

    • Author Affiliations


      G. V. Ramana1 A. Vasanthi2 M. Khaja2 B. Su1 3 V. Govindaiah4 L. Jin1 3 L. Singh5 R. Chakraborty1 3

      1. Human Genetics Center, School of Public Health, University of Texas, P.O. Box 20186, Houston, TX - 77225, USA
      2. Department of Genetics, Owaisi Medical and Research Centre, Deccan College of Medical Sciences and Allied Hospitals, Kanchan Bagh, Santosh Nagar, Hyderabad - 500 058, India
      3. Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati, OH - 46267, USA
      4. Centre for DNA Fingerprinting and Diagnostics, 4-87/1 ECIL Road, Nacharam, Hyderabad - 500 076, India
      5. Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500 007, India
    • Dates

  • Journal of Genetics | News

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