• Fulltext


        Click here to view fulltext PDF

      Permanent link:

    • Keywords


      male infertility; polymorphism; Y chromosome; mitotic instability

    • Abstract


      During a study of deletions of Y-chromosomal DNA in infertile males, sY116, a Y-linked STS, showed different electrophoretic mobilities in three males, two infertile and one fertile. A study of this STS among 35 other normal males showed that this locus is polymorphic. sY1 16 has a polyA-rich stretch whose instability appears to be the most likely cause of this polymorphism. The possible usefulness of sY116 polymorphism in the detection of subtle genome-wide instabilities in some types of cancer is discussed.

    • Author Affiliations


      G. Mustafa Saifi1 Reiner Veitia2 Houssein Khodjet El Khil3 Sandrine Barbaux2 Preetha Tilak4 I. Manorama Thomas4 Marc Fellous2

      1. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore - 560012, India
      2. Immunogénétique Humaine, Institut Pasteur, Paris, Cedex 15 - 75724, France
      3. Faculté de Sciences de Tunis, Laboratoire d’Immunogénétique, Tunis, Tunisia
      4. Department of Anatomy, St John’s Medical College, Bangalore - 560034, India
    • Dates

  • Journal of Genetics | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.