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      https://www.ias.ac.in/article/fulltext/jgen/078/02/0099-0121

    • Keywords

       

      microsatellite loci; genetic variation; gene diversity; human populations

    • Abstract

       

      We have analysed genetic variation at 23 microsatellite loci in a global sample of 16 ethnically and geographically diverse human populations. On the basis of their ancestral heritage and geographic locations, the studied populations can be divided into five major groups, viz. African, Caucasian, Asian Mongoloid, American Indian and Pacific Islander. With respect to the distribution of alleles at the 23 loci, large variability exists among the examined populations. However, with the exception of the American Indians and the Pacific Islanders, populations within a continental group show a greater degree of similarity. Phylogenetic analyses based on allele frequencies at the examined loci show that the first split of the present-day human populations had occurred between the Africans and all of the non-African populations, lending support to an African origin of modern human populations. Gene diversity analyses show that the coefficient of gene diversity estimated from the 23 loci is, in general, larger for populations that have remained isolated and probably of smaller effective sizes, such as the American Indians and the Pacific Islanders. These analyses also demonstrate that the component of total gene diversity, which is attributed to variation between groups of populations, is significantly larger than that among populations within each group. The empirical data presented in this work and their analyses reaffirm that evolutionary histories and the extent of genetic variation among human populations can be studied using microsatellite loci.

    • Author Affiliations

       

      Ranjan Deka1 2 Mark D. Shriver3 Ling Mei Yu4 Elisa Mueller Heidreich4 Li Jin5 Yixi Zhong5 Stephen T. Mcgarvey6 Shyam Swarup Agarwal7 Clareann H. Bunker8 Tetsuro Miki9 Joachim Hundrieser10 Shih-Jiun Yin11 Salmo Raskin12 Ramiro Barrantes13 Robert E. Ferrell4 Ranajit Chakraborty5

      1. Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
      2. Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P.O. Box 670056, Cincinnati, OH - 45267-0056, USA
      3. Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania, USA
      4. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
      5. Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA
      6. Department of Medicine and International Health Institute, Brown University, Providence, Rhode Island, USA
      7. Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
      8. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
      9. Department of Geriatric Medicine, Ehime University, Ehime, Japan
      10. Klinik für Abdominal und Transplantationschirurgie, Medizinische Hochschule, Hannover, Germany
      11. Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan
      12. Universidade Federal do Parana, Curitiba, Brazil
      13. Instituto de Investigaciones en Salud, Universidad de Costa Rica, San Jose, Costa Rica
    • Dates

       
  • Journal of Genetics | News

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