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    • Keywords


      Vitiligo; multilocus recessivity; segregation analysis

    • Abstract


      Vitiligo is a dermatological disorder in man that shows familial aggregation. We performed segregation analysis on data pertaining to vitiligo on members of 147 pedigrees each ascertained through a single proband, and tested various non-genetic, and one-locus and two-locus genetic models. Non-genetic and one-locus genetic models were rejected in favour of a two-locus model postulating epistatic interaction of recessive alleles in the aetiology of vitiligo. The present results show that vitiligo is not a single-locus disorder and substantiate our earlier inference, drawn on the basis of nuclear-family data, of multilocus involvement in the pathogenesis of vitiligo.

    • Author Affiliations


      Swapan K. Nath1 James J. Nordlund2 Partha P. Majumder1

      1. Anthropometry and Human Genetics Unit, Indian Statistical Institute, 203 B.T. Road, Calcutta - 700 035, India
      2. Department of Dermatology, University of Cincinnati Medical Center, Cincinnati, OH - 45267, USA
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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