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Vitiligo; multilocus recessivity; segregation analysis

Vitiligo is a dermatological disorder in man that shows familial aggregation. We performed segregation analysis on data pertaining to vitiligo on members of 147 pedigrees each ascertained through a single proband, and tested various non-genetic, and one-locus and two-locus genetic models. Non-genetic and one-locus genetic models were rejected in favour of a two-locus model postulating epistatic interaction of recessive alleles in the aetiology of vitiligo. The present results show that vitiligo is not a single-locus disorder and substantiate our earlier inference, drawn on the basis of nuclear-family data, of multilocus involvement in the pathogenesis of vitiligo.

Swapan K. Nath¹ James J. Nordlund² Partha P. Majumder¹

1. Anthropometry and Human Genetics Unit, Indian Statistical Institute, 203 B.T. Road, Calcutta - 700 035, India
2. Department of Dermatology, University of Cincinnati Medical Center, Cincinnati, OH - 45267, USA

Published

8 April 1995

Manuscript received

1 August 1995