Pedigree analysis of vitiligo: Further support for multilocus involvement
Swapan K. Nath James J. Nordlund Partha P. Majumder
Click here to view fulltext PDF
Permanent link:
https://www.ias.ac.in/article/fulltext/jgen/074/01-02/0041-0046
Vitiligo is a dermatological disorder in man that shows familial aggregation. We performed segregation analysis on data pertaining to vitiligo on members of 147 pedigrees each ascertained through a single proband, and tested various non-genetic, and one-locus and two-locus genetic models. Non-genetic and one-locus genetic models were rejected in favour of a two-locus model postulating epistatic interaction of recessive alleles in the aetiology of vitiligo. The present results show that vitiligo is not a single-locus disorder and substantiate our earlier inference, drawn on the basis of nuclear-family data, of multilocus involvement in the pathogenesis of vitiligo.
Swapan K. Nath1 James J. Nordlund2 Partha P. Majumder1
Volume 102, 2023
All articles
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode
© 2022-2023 Indian Academy of Sciences, Bengaluru.