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    • Keywords


      Segregation analysis; autosomal recessive; multiple loci; variable onset age; prelingual deafness; vitiligo

    • Abstract


      A genetic model is discussed for recessively inherited disorders that do not follow a single-locus Mendelian pattern of inheritance. Further complexity arising from variable age of onset is also discussed. Methods of statistical analysis of family data using the likelihood principle are described for such complex disorders. The methods are exemplified using data on families of prelingual deafness and vitiligo.

    • Author Affiliations


      Partha P. Majumder1 Swapan K. Nath1

      1. Anthropometry & Human Genetics Unit, Indian Statistical Institute, Calcutta - 700 035, India
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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