TheInt family of site-specific recombinases: Some thoughts on a general reaction mechanism
The FLP recombinase of the yeast 2 micron circle plasmid belongs to theInt family of recombinases. Only three amino acid residues are invariant among members of this family. Functional analyses of FLP protein variants mutated at these three residues suggest their involvement at specific steps of the recombination pathway. We propose that these residues play the same functional role in the mechanism of action of all theInt family recombinases.
Volume 100, 2021
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