• Cytogenetic analysis of the actions of carcinogens and tumour inhibitors inDrosophila Melanogaster - III. Chromosome structural changes induced by 2:4:6-Tri(Ethyleneimino)l:3:5-Triazine

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    • Abstract

       

      Chromosome rearrangements induced by various doses of 2:4:6-tri(ethyleneirnino)-l:3:5-triazine inDrosophila sperm have been studied in theF1 offspring: cytologioally in the X-salivary chromosomes of larvae, and genetically by the scoring of theMinute mutation. The majority of the rearrangements were of the same types as those induced by X-radiation, viz, simple and complex interstitial aberrations and no single-break, terminal ones. There were also partial rearrangements involving less than half of the treated chromosome which have not so far been reported in the X-ray material. The frequency of mosaic rearrangements is much higher than after X-radiation. At low and moderate doses there were as many mosaic aberrations as there were completes, but at the higher doses mosaics were less.

    • Author Affiliations

       

      O. G. Fahmy1 Myrtle J. Fahmy1

      1. Chester Beatty Institute of Cancer Research, The Royal Cancer Hospital, S.W. 3, London
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  • Journal of Genetics | News

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