A mosaic mouse with an anomalous segregation ratio
A mouse, heterozygous for the semi-dominant colour and anaemia mutantWv, showed two patches of full pigmentation (i.e. lackingWv); she bred as though her ovaries were partly deficient of the type allele +w. Point mutation and deletion fail to provide satisfactory explanations; non-disjunction provides a possible explanation; somatic reduction and somatic crossing-over, not previously considered as possible mechanisms of mammalian mosaic formation, would fit the facts well. They could also account for some other mosaic mammals which were hitherto difficult to explain. It is established thatWv, like other mutants, is autonomous in its action on pigmentation.
Volume 100, 2021
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