A radiation method for determining the number of genes in theX-chromosome ofDrosophila
It is known experimentally that the efficiency of production of sex-linked lethal mutations inDrosophila melanogaster by radiation is, per ionization, less for densely ionizing radiations (neutrons) than for less densely ionizing radiations (X-rays). A theory is given correlating this effect with the target volume of the individual genes. The estimate of the target volume obtained by this method agrees with the estimate obtained by methods already known. It is further shown that on this theory the experimentally determined ratio of the mutation rates for X-rays and neutrons may be used to give an estimate of the number of genes in theX-chromosome ofDrosophila. Using the experimental figure of 1·6 for the ratio of the mutation rates, the number of genes in theX-chromosome is deduced to be 1860.
Volume 100, 2021
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