The problem of dominance in man
1. The majority of pathological genes in man:
are conditionally dominant, showing a definite expression in the heterozygote, and
have poor penetrance. This is true both for autosomal as well as for sex-linked genes.
2. Conditionally dominant genes (in the heterozygote) tend to be expressed later in ontogeny than recessive genes (in the homozygote).
3. An explanation is given for these phenomena from the point of view of the evolution of dominance.
Volume 100, 2021
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