• A contribution to the relation of the gene loci involved in the isoagglutinin reaction, taste blindness, Friedreich’s ataxia and major brachydactyly of man

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    • Abstract

       

      The following conclusions may now be stated:

      1. Friedreich’s ataxia is determined by a single recessive gene substitution (f).

      2. The locusF-f is not strongly linked toT-t (phenyl-thio-urea taste blindness) orA-B-R (isoagglutinin reaction). As far as the present evidence permits any inference it appears to segregate independently.

      3. The locusBr-br (brachydactyly) is not strongly linked toT-t, neither isA-B-R. The data are insufficient to justify the statement thatA-B-R orBr-br segregates independently with respect toT-t.

      4. The yield of relevant information obtained in linkage studies confined to a few genes is very small. In consequence the method of routine testing of hospital patients with a battery of tests would seem to be the most efficient way of advancing the mapping of human chromosomes.

    • Author Affiliations

       

      Lancelot Hogben1 Ray Pollack1

      1. From the Department of Social Biology, University of London, UK
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  • Journal of Genetics | News

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