The following conclusions may now be stated:
Friedreich’s ataxia is determined by a single recessive gene substitution (f).
The locusF-f is not strongly linked toT-t (phenyl-thio-urea taste blindness) orA-B-R (isoagglutinin reaction). As far as the present evidence permits any inference it appears to segregate independently.
The locusBr-br (brachydactyly) is not strongly linked toT-t, neither isA-B-R. The data are insufficient to justify the statement thatA-B-R orBr-br segregates independently with respect toT-t.
The yield of relevant information obtained in linkage studies confined to a few genes is very small. In consequence the method of routine testing of hospital patients with a battery of tests would seem to be the most efficient way of advancing the mapping of human chromosomes.
Volume 100, 2021
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