On the interaction of heredity and environment in the study of human genetics (with special reference to Mongolian imbecility)
The effect of environment in the study of human genetics has been discussed, especially in relation to the observation of numerical ratios of affected persons to normal where the inheritance, not of a disease, but of the susceptibility to a disease is under consideration.
Methods of allowing for the effects of environments of graded intensity have been investigated.
The problem of selective mortality of affected individuals has been discussed, and a solution proposed.
The importance of the possibility of parents themselves being susceptible persons has been considered.
The methods which are described for attacking these problems are applied to data on the familial incidence of mongolian imbecility, which is assumed to have some hereditary basis. It is concluded that, if due allowance be made for environment, the proportion of susceptible individuals must be very much higher than is usually supposed in affected families.
It is concluded that the susceptibility to mongolism may possibly be determined by the inheritance of two dominant genes.
Volume 100, 2021
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