This paper discusses an experimental approach to examine uranium exploration avenue over the geologicallyextended parts of Mahadek basin in Meghalaya, amid some of the environmental constraints. Studycomprises periodic measurements of prevailing ambient gamma levels across 320 georeference points, inrelation to the major litho units of Mahadek basin, covering 673 line km of Khasi Hills. Acquired sampledata points were then analysed in geostatistical software (Surfer^{TM}) to develop analytical model of samplevariogram having bearing on the uranium exploration in the area. Study findings have given encouragingsurface indicators with mostly elevated gamma levels over the parts of West Khasi Hills. Delineatedgamma anomalous zones are lithologically well correlated including to that of existing uranium occurrencesin the basin. Identified anomalous zones over the parts of West Khasi Hills by this study work, aremainly associated with the Mahadek sandstone (Upper and Lower Mahadek) and Precambrian basementgranites. Lower Mahadek sandstone is host rock for uranium mineralisation in the basin. Initial findingssuggest with the closer spatial resolution (∼1 km) of sample data points, the approach adopted by thestudy work holds promising application in locating potential uranium exploration targets especially tothe extended and inaccessible parts of the basin.